Tolectin Capsule

Rheumatoid arthritis, Osteoarthritis

Oral Rheumatoid arthritis; Osteoarthritis Adult: Initially, 200-600 mg tid. Maintenance: 600-1800 mg daily in 3 divided doses. Max: 1800 mg/day.

Oral Juvenile idiopathic arthritis Child: >2 yr: Initially, 20 mg/kg daily in 3-4 divided doses. Maintenance: 15 mg/kg/day. Max: 30 mg/kg/day.

Renal impairment: Dose adjustment may be needed.

Should be taken with food. Take w/ or immediately after meals.

Pregnancy (3rd trimester), hypersensitivity to aspirin and NSAIDs, treatment of perioperative pain in CABG surgery.

Lactation, elderly. Impaired renal and hepatic function. CV diseases, fluid retention, heart failure, history of GI bleed or gastric ulcer, dehydration, hypertension. Monitor renal function regularly.

C Pregnancy Category: C; avoid in late pregnancy, may cause premature closure of ductus arteriosus Lactation: excreted in breast milk; safety in nursing infants not known

Decreases the efficacy of mifepristone. Increased risk of bleeding with anticoagulants, other NSAIDs, antiplatelets, LMWH. Increased risk of convulsions with quinolones. Decreased antihypertensive response to loop diuretics, beta-blockers and ACE inhibitors. Coadmin increased plasma concentrations of lithium, methotrexate and cardiac glycosides. Increased risk of nephrotoxicity with ACE inhibitors, penicillamine, ciclosporin, tacrolimus or diuretics.

>10% Increased liver function test (up to 15%) 1-10% Nausea (10%),Hypertension (3-9%),Myocardial infarction (<2%),Edema,Weight gain, Weight loss,Abdominal pain,Diarrhea,Flatulence,Indigestion,Nausea, Vomiting,Asthenia,Dizziness,Headache <1% Thrombotic tendency observations,Erythema multiforme,Scaling eczema,Stevens-Johnson syndrome,Toxic epidermal necrolysis,Gastrointestinal hemorrhage,Gastrointestinal perforation,Inflammatory disorder of digestive tract,Agranulocytosis,Anemia,Neutropenia,Thrombocytopenia,Jaundice,Liver failure,Anaphylactoid reaction,Cerebrovascular accident,Acute renal failure,Hematuria,Proteinuria,Bronchospasm Potentially Fatal: Blood dyscrasias, serious CV thrombotic events, hepatitis, Stevens-Johnson syndrome.

Tolmetin decreases cyclooxygenase activity consequently decreasing formation of prostagladin precursors and inhibiting prostaglandin synthesis.

Tolectin 200 mg Capsule manufactured by Synovia Pharma PLC. Its generic name is Tolmetin.