Doxiderm Cream

Pruritus, Chronic idiopathic urticaria (hives), Atopic dermatitis, lichen simplex chronicus

Adult: apply thinly 3-4 times daily; usual max. 3 g per application; usual total max. 12 g daily; coverage should be less than 10% of body surface area. Use in Elderly Patients: Dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range.

Child over 12 years: apply thinly 3-4 times daily; usual max. 3 g per application; usual total max. 12 g daily; coverage should be less than 10% of body surface area. The use of Doxepin cream in pediatric patients is not recommended.

Patients with untreated narrow angle glaucoma or a tendency to urinary retention because doxepin HCl has an anticholinergic effect Individuals who have shown previous sensitivity to any of its components

Cautions should be exercised if there is susceptibility to angle-closure glaucoma, urinary retention, severe liver impairment, mania and also in pregnancy and breast-feeding. Drowsiness may affect performance of skilled tasks (e.g. driving) so patient should be careful. Lactation: may pass into breast milk; do not nurse

B Pregnancy Category: B Lactation: May pass into breast milk; do not nurse

Methylphenidate may increase plasma doxepin levels. Potentially Fatal: Potentiates hypertensive action of sympathomimetics. Increased anticholinergic effects with MAOIs. Additive CNS effects with anticholinergics, CNS depressants and alcohol.

>10% Burning/stinging (23%),Drowsiness (20%; esp if applied to >10% BSA) 1-10% Dizziness,Dry mouth,Eczema exacerbated,Edema,Fatigue,Mental changes,Pruritus,Taste perversion

Potent histamine H1- & H2-receptor antagonist activity.

Doxiderm 50mg/1g Cream manufactured by Incepta Pharmaceuticals Ltd.. Its generic name is Doxepin 5% Topical.