Orthogen Tablet

Osteoarthritis & rheumatoid arthritis, Difficulties in flexibility & mobility, Joint pain & inflammation, Joint discomfort & stiffness (knee extension), Impaired Joint function, Deficiency of calcium & minerals

Route of administration : Orally. 1 tablet twice daily after meal. Or as directed by the physician.

Contraindicated in patients with known hypersensitivity to chicken, egg & shellfish.

In the presence of Glucosamine, diabetics patients are advised to monitor blood glucose labels regularly. No special studies were confirmed in patients with renal and /or hepatic insufficiency. However administration to these patients with severe renal or hepatic insufficiency should be under appropriate medical supervision.

Not recommended duration pregnancy and lactation. Use in children & adolescents Safety and effectiveness in children patients below 12 years of age have not been established.

There have been no reports of significant drug Interactions of undenatured collagen II, Boswelliaserrata, Glucosamine sulfate, Calcium fructoborate. But in case of Glucosamine sulfate &Boswelliaserrata there are a chance of drug interaction with blood thinner medications (e,g warfarin, heparin).

The most common adverse reactions associated with treatment with glucosamine are nausea, abdominal pain, indigestion, constipation, and diarrhoea. Boswellia may increase side effects of other drugs, including antidepressants, anti-anxiety medications, ibuprofen and immunosuppressants.

In patients affected by this disease, chondrocytes can become activated to release pro-inflammatory cytokines due to environmental stress. Due to these postulated effects on cartilage turnover processes, the hypothesis is that glucosamine sulfate may serve a role in managing osteoarthritis. Glucosamine (2-amino-2-deoxy-?-d-glucopyranose) is an endogenous aminomonosaccharide synthesized from glucose and utilized for biosynthesis of glycoproteins and glycosaminoglycans.Glucosamine is present in almost all human tissues, highly concentrated in connective tissues of the human body, and found at highest concentrations in the cartilage. In humans, about 90 percent of glucosamine is absorbed when administered as an oral dose of glucosamine sulfate, and is rapidly incorporated into articular cartilage. Undenatured Collagen Type II is non-hydrolysed collagen with intact structure, active epitopes and antigenicity, which is lost in hydrolysed collagen. Undenatured type II collagen is extracted from chicken sternum using little or no heat (unlike the high heat used in hydrolysed collagen), and very limited processing just enough to concentrate the collagen and make it soluble. The manufacturing process ensures that the collagen remains biologically active in its most native, triple helix form with antigenic sites (epitopes) intact for immunomodulation. Boswellic acid, the major constituent of boswellia, is thought to contribute to many of the herb’s pharmacological activities. Preclinical studies show that anti-inflammatory activity occurs via inhibition of 5-lipoxygenase and cyclooxygenase-1. Boswellic acid also inhibits nuclear transcription factor KappaB (NF-KappaB) signaling, markedly decreasing production of the key proinflammatory cytokine tumor necrosis factor (TNF-alpha) Mechanism of Action of Calcium FructoborateSubsequently, the most probable action mechanism of CF may be the chemical bonding of fructoborate to specific cytokines glycoproteic receptors at the surface of the cellular membrane.

Orthogen 20mg + 750mg + 50mg & 0.75 mg. Tablet manufactured by Acme Laboratories Ltd.. Its generic name is Glucosamine sulfate + Undenatured Type II collagen + Boswellia serrata + Boron.